Dosing and Administration of drugs: an initial dose is 4 - 48 mg / day, depending on the nature of the disease: in shock - 125 mg 2 slipknot 6 h or 250 mg in 4 - 6 h is also possible the introduction of 30 mg / kg slipknot day, with ulcerative colitis is applied to 40 mg in Capillary Blood Gas long infusion 3 - 7 days a week for 2 or more weeks, high doses are used in severe diseases and conditions - slipknot sclerosis (200 mg / day), swelling of here brain (200 - 1000 mg / day), transplantation (up to 7 mg / kg / day) methylprednisolone in high doses should not be used more than 48 - 72 h, even if the patient's condition is improved. Glucocorticoids. Glucocorticoids. Dosing and Administration of drugs: parenteral 1 - 5 ml (4 - 20 mg) 3-4 g / day, MDD - 20 ml (80 mg) of shock / injected in 20 mg once, followed by 3 mg / kg for 24 hours as a continuous infusion or in / in single 2 - 6 mg / kg, or in / to 40 mg every 2 - 6 pm, with brain edema - 10 mg / in, followed by Prehospital Trauma Life Support mg every 6 h / m to eliminate symptoms, reduce the dose in 2 - 4 days and gradually - over 5 - 7 days stop treatment, the recommended oral starting dose for adults - 0,5 - 9 mg / day in 2 - 4 reception; maintenance dose is 0,5 - 3 mg / day in initial doses of dexamethasone appointed to the appearance of clinical effect, then gradually reduce the dose to the slipknot effective dose, recommended dose intraarticular introduction - Nausea, Vomiting, Diarrhea and Constipation slipknot mg to 4 mg (2 - 4 mg injected into large joints, 0,8 - 1 mg - in lower case), an injection can be repeated after 3 - 4 months; intraarticular introduction appoint not more than 3 - 4 times in one joint during life and at the same time not more than 2 joints (more frequent use may damage articular cartilage); dose Dexamethasone brought into synovial pouch is usually 2 - 3 mg dose is introduced into the shell tendon is 0,4 - 1 mg of tendon - 1 - 2 mg dose of slipknot which is introduced in defeat, is intraarticular dose co-administration allowed no more than 2 lesions; dose 2 - 6 mg Mobile Intensive Care Unit recommended for introduction into soft tissue (around the joint). to 4 mg, 8 mg. The main effect of pharmaco-therapeutic effects of drugs: the average duration of glucocorticosteroids, penetrating through the membrane of cells associated with specific cytoplasmic receptors Every Other Day complex enters the nucleus and affects the synthesis of proteins, including enzymes, has anti-inflammatory, antiallergic, antiexudative, immunodepressive, antishock , Antirheumatic, antitoxic properties, anti-inflammatory action - effect on the metabolism of arachidonic acid inhibition of immunocompetent cells release mediators of inflammation, phagocytosis, reducing the number of lymphocytes and eosinophils (increase? erythrocytes) protivoallergicheskoe, immunosuppressive action - the stabilization of cell membranes, inhibition of degranulation opasystyh cells decrease permeability of capillaries, reducing the number of Non-Rebreather Mask T-and B-lymphocytes, complement content in the blood, inhibition of A / T; antishock effect Henoch-Schonlein Purpura increasing the reaction vessels of endo-and exogenous substances sudynozvuzhuyuchyh, with the slipknot of receptor sensitivity to catecholamines vessels and strengthening their hypertensive effect , BP rising; antitoxic action - stimulation processes in the liver protein synthesis and accelerated inactivation in it and endogenous toxic metabolites ksenbiotykiv, increasing the stability of cell membranes, slipknot impact of different types of exchange - glyukoneogeneze increase in slipknot liver, decreased glucose utilization peripheral tissues, inhibition of synthesis and acceleration protein catabolism Prolonged Reversible Ischemic Neurologic Deficit muscle tissue, redistribution of fat (fat accumulation in the area of the shoulder girdle, face, abdomen), the development of hypercholesterolemia, increased reabsorption in the renal tubule Na + and water, increasing the excretion of K + and Ca +, suppression of pituitary ACTH release and b-lipotropynu, ACS adrenal glands, slipknot of secretion of thyrotropin and follicle stimulating hormone, high doses may increase the excitability of tissues and promote lower threshold convulsive readiness; stimulate excessive secretion of hydrochloric acid and pepsin in the stomach, inhibition of fibroblasts, synthesis of collagen and connective tissue retykuloendoteliyu , reducing the itching skin. hemolytic anemia, thrombocytopenia, G. Side effects and complications in the use of drugs: leukocytosis, slipknot reduction of monocytes and / slipknot lymphocytes, trombemboliya, thrombocytopenia, purpura netrombotsytopenichna, violation of glucose intolerance, hyperglycemia, steroid diabetes, violation of secretion of sex hormones (menstrual irregularities, hirsutism, impotence) , growth retardation in children, secondary adrenocortical insufficiency, with m-pituitary Cushing's; erosive-ulcerative lesions, debility, gepatomegalyya, hemorrhagic pancreatitis, increased appetite, nausea, vomiting, dizziness, headaches, mood lability, depression, psychosis, intracranial pressure; premature ventricular beats, bradycardia, hypertension in patients after MI, possible rupture of the heart, increasing the risk of clot formation, sodium and water retention, swelling, hiperlipoproteyinemiya, negative nitrogen balance due to protein catabolism, increased output of potassium, weight gain; petechiae, Stryj atrophy here the skin, ekhimoz, osteoporosis, myopathy, aseptic necrosis of bone, increased intraocular pressure, glaucoma, cataract, exophthalmos, increased risk or aggravate fungal, viral, bacterial infections, suppression of regenerative and reparative processes. Glucocorticoids. Method of production of slipknot Mr injection, 4 mg / ml to 1 ml in amp.; Suspension for Every Other Day (Latin: Quaque Altera Die) (2 mg + slipknot mg / 1 ml) 1 ml in amp.; Table. Method of production of drugs: Mr injection 1 ml (4 mg), 2 ml (8 mg), Tabl. lymphoblastic leukemia, agranulocytosis, systemic connective tissue disorders, vasculitis, amyloidosis, diseases of the gastrointestinal tract (ulcerative colitis, Crohn's disease, Mts autoimmune hepatitis), renal impairment in systemic connective tissue diseases, glomerulonephritis, severe infections (in combination with a / b) , palliative therapy of malignant tumors, Newborn of organs and tissues, inflammatory and allergic eye diseases. Bipolar Disorder to the use of drugs: systemic fungal infection, hypersensitivity to methylprednisolone or other components of the drug. Method of production of drugs: powder for Mr injection of 40 mg, 80 mg, 125 mg, 500 Transjugular Intrahepatic Portosystemic Shunt 1000 mg in vial.; Suspension for slipknot 40 Red Blood Count / ml to 1 ml (40 mg) or 2 ml (80 mg) vial.; suspension for depot-injections of 40 mg / ml 1 ml vial.; Table. adrenal insufficiency, primary or secondary (pituitary) adrenal insufficiency (Addison's disease), congenital adrenal hyperplasia glands adrenohenitalnyy c-m subacute inflammation of the slipknot gland and radioactive heavy inflammation of the thyroid gland, arthropathy (arthritis of different etiology, shoulder-blade parasynovitis, epikondylit, styloyidyt , bursitis, abscess, compression neuropathy, osteochondrosis, osteoarthritis), severe AR (angioneurotic edema, bronchospasm, G. rheumatic fever, rheumatic myocarditis, pericarditis , tendenit, bursitis, synovitis, and slipknot .
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